고분자 겔
Stimuli-sensitive polymer
Environmental Stimuli
pH, temperature, electrical field, ionic strength, salt type, solvent, light
Response
Change in shape, surface characteristics, solubility, molecular self-assembly, sol-to-gel transition
Stimuli-sensitive polymer의 특성
Stimuli-sensitive property
Behavior : intra or intermolecular interaction of polymer chain
Driving forces : van der Waals interaction, hydrophobic interaction, hydrogen bonding, electrostatic interaction
Stimuli-sensitive hydrogel
Crosslinking
Physical : temperature, ionic strength, solvent, UV/VIS light, electric field, magnetic field
Chemical : pH, specific ions, chemical species
Biological : enzyme, glucose, antigen, other biomolecules
Thermosensitive polymer
Poly(N-isopropyl acrylamide)
LCST : 32℃
Hydrophilic : acrylic acid, N,N-diethylaminoethyl methacrylate, acrylamide - LCST 증가
Hydrophobic : butyl methacrylate LCST 감소
Poloxamer : LCST 10~100℃
PLA or PLGA-PEO block or graft copolymer : biodegradable
Thermosensitive polymer
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2013.05.01
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