효소측정의 임상적 응용


1. 실험제목 : 효소측정의 임상적 응용
2. 실험원리 :
<개요>
■1. Mechanism for abnormal serum enzyme level
￭I. Increased level
•A. Increased release
∙a. Necrosis : Myocardial infarction(AST, LD, CK, HBDH)
Acute Hepatitis(AST, ALT, OCT LD, LAP)
Acute pancreatitis(Amylase, Lipase)
∙b. Increased permeability without necrosis
: Progressive muscular dystrophy(CK, ALS, LD)
•B. Increased tissue source of enzyme
: Neoplastic disease (carcinoma, lymphoma, leukemia)(LD, ALS)
Megaloblastic anemia(LD, ALS)
Osteoblastic lesion(Paget's disease, osteogenic sarcoma, rickets, healing fracture)(ALP)
•C. Impaired excretion of enzyme
: Uremia (Pepsinogen, Amylase)
Obstructive jaundice( ALP, LAP, r-GT, 5'-N)
￭II. Decreased level
•A. Decreased formation
∙a. Genetic : Hypophosphatasia(ALP)
Wilson's disease(Ceruloplasmin)
Acholinesterasemia(Pseudocholinesterase)
∙b. Acquired : Hepatitis(Pseudocholinesterase)
Starvation(Amylase)
....

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